Pilot study test combination
of n-acetylcysteine and Copaxone as potential MS treatment
Summary
A small pilot study is underway in Quebec to test whether
combining a frequently used anti-oxidant supplement called N-acetylcysteine
(NAC) with glatiramer acetate (Copaxone®) will
improve Copaxone’s effectiveness. Eighteen people who have
relapsing-remitting MS are taking part in the open-label study
at two research centres. The study is examining the efficacy,
tolerability and safety of the two products in combination.
Details
The 46-week study involving 18 people
with relapsing-remitting MS is taking place at two study
sites: the Jewish General Hospital in Montreal and the Neuro-Rive
Sud MS Clinic in Greenfield Park. Dr. Hyman Schipper at the
Jewish General Hospital is the lead investigating neurologist.
There is some evidence that adding NAC
may enhance Copaxone’s ability to protect nerve fibres
(neuroprotection) and possibly slow the progression of the
disease.
Copaxone is approved by Health Canada
as a treatment for relapsing-remitting MS. It is administered
daily by under the skin injections. (For more information
see the medical update memo MS
Disease Modifying Therapies in Canada, June 30,
2004)
N-acetylcysteine is an altered form of
an amino acid, which is commonly found in food and synthesized
by the body. It is an anti-oxidant with potential neuroprotective
qualities.
Results of the combination therapy will
be assessed using both MRI and clinical measures.
The study is sponsored by Teva Neuroscience.
ASK MS Information System Code:
1.4.1.28
Click here to
view or print this bulletin in its original format.
Disclaimer
The Multiple Sclerosis Society of Canada is an independent,
voluntary health agency and does not approve, endorse or
recommend any specific product or therapy but provides information
to assist individuals in making their own decisions.
Charitable registration
10774 6174 RR0001
Multiple Sclerosis Society of Canada
Toll free to reach
the nearest regional office: 1 800 268-7582
To locate the MS Society office near you, please select your region:
E-mail: info@mssociety.ca (Please provide your town and
province in your e-mail)
