View or print the application process for the Request for Research Operating Grants in its original format.
The Multiple Sclerosis Society of Canada (the MS Society) invites research operating grant proposals on the topic of chronic cerebrospinal venous insufficiency (CCSVI) and its possible relationship to Multiple Sclerosis (MS).
The studies from this initiative should help to further develop the current research ideas of the association between CCSVI and MS and determine whether the potential treatment of CCSVI warrants further investigation into potential implication in individuals with MS.
In two recent articles, Zamboni et al.(J Neurol Neurosurg Psychiatry 2009; 80:392-399) (J Vasc Surg 2009; 50:1348-58) propose that impaired venous drainage from the brain and spinal cord, termed by the authors ‘chronic cerebrospinal venous insufficiency’ (CCSVI), is the primary cause of MS and that percutaneous transluminal opening of the veins is a potential treatment option for this disease. These preliminary results raise the possibility that CCSVI may be involved in the pathogenesis of MS and suggest that further investigation of this concept is warranted.
The MS Society remains committed to supporting investigator-initiated research that seeks to understand the cause, prevention and cure of MS through its traditional funding mechanisms. However, the MS Society recognizes the need to further investigate the subject of CCSVI and its possible relationship to MS in a particularly timely fashion. As the published research on this topic is preliminary and restricted to a single medical center, it will require replication and validation in multiple well-designed studies so that its potential importance in MS can be scientifically clarified.
It is expected that the person indicated as the Principal Investigator in an application for a grant is the one who is personally and actively responsible for the conduct of the research and who is considered eligible by his or her Canadian institution to apply for a research grant. The following requisite expertise must be part of the application: an expert in medical imaging and a clinical MS expert. The Principal Investigator must be conducting research in a Canadian institution.
This funding opportunity will comply with the MS Society’s operating research grants policies and procedures. For further details regarding the conditions of this funding program, please view the MS Society Research Funding Program and Awards Policies and Procedures on the MS Society’s research webpage: www.mssociety.ca/en/research/researchfunding.htm
The MS Society has a long history and well established policies of requesting research applications in both official languages. On an exceptional basis, this Request for Research Operating Grants is issued in English only reflecting the short timeline for the launch of the competition. As a result, those responding to this Request for Research Operating Grants are asked to complete their application in English only.
A Letter of Intent (LOI) must be submitted prior to submitting the full research proposal. The peer review process of the LOI will be conducted by the MS Society’s Medical Advisory Committee (MAC)
The review criteria for the LOI include:
Following the review of the LOI, full applications will be invited. The review of the full applications of the research operating grants will be done by an international panel assembled by the MS Society and the National MS Society (NMSS) (USA). This panel will review applications from the MS Society, NMSS and any other request for applications released by other MS Societies that also address the topic of CCSVI and its relation to MS. The MS Society will initially review the applications for completeness and relevance. Applications that are not deemed to be complete or relevant will be excluded from the competition. The MS Society uses the Canadian Institute of Health Research (CIHR) common scale for scoring
The review criteria for the full application include:
To complete your application, please go to https://www.mscanadagrants.ca
There are two stages to the application process:
I. Letter of Intent
All interested applicants must submit a Letter of Intent (LOI) by 11:59 p.m. EST on January 6th, 2010. The LOI will be used to assess for relevance to this request for research operating grant and invitation will be used to submit a full application based on the LOI.
The online submission of the LOI consists of:
II. Full Application
On January 12th, 2010, invitations will be issued to applicants to submit a full research proposal. Applicants must submit their application no later than 11:59pm EST on February 9th, 2010. Incomplete or late applications will NOT be accepted.
The full online application consists of:
For further information please contact:
Karen Lee, Ph.D.
Multiple Sclerosis Society of Canada
Toll free to reach the nearest regional office: 1 800 268-7582
To locate the MS Society office near you, please select your region: