Affiliation(s): University of British Columbia
Dr. Moore graduated with a BSc degree (Biology major) from Memorial University of Newfoundland in 1968 and with an MD, CM degree from McGill University in 1972. He completed his internship at the Royal Victoria Hospital in Montreal in 1973, after which he practiced general medicine in a cottage hospital in Port-aux-Basques, Newfoundland for one year. From 1974 to 1977, he was a resident in neurology at the Mayo Clinic in Rochester, Minnesota. From 1977 to 1980, he was a resident in neuropathology at Queen’s University in Kingston, Ontario. He is certified by The Royal College of Physicians and Surgeons of Canada in neurology and in neuropathology and is board-certified in adult neurology by the American Board of Psychiatry and Neurology and in neuropathology by the American Board of Pathology; He also is a Fellow of The Royal College of Pathologists (UK). After his residencies, he obtained a faculty position at Memorial University of Newfoundland in the Disciplines of Medicine (Neurology) and Pathology (Neuropathology) from 1980 to 1982. From 1982 to 1986, he was funded by the Multiple Sclerosis Society of Canada as a post-doctoral fellow in experimental neuropathology and multiple sclerosis (MS) neuropathology and neuroimmunology research in Dr. C.S. Raine’s laboratory at the Albert Einstein College of Medicine in New York. From 1986 to 1988, he was Assistant Professor of Pathology (Neuropathology) and Neurology at Albert Einstein College of Medicine. In 1988, he moved to the University of British Columbia as a diagnostic neuropathologist and as a researcher in MS neuropathology, where he is currently Clinical Professor of Pathology and Laboratory Medicine with a cross-appointment in Medicine (Neurology). His research focuses on the pathology and pathogenesis of MS and how they relate to the appearance of the disease on magnetic resonance imaging (MRI). In recent years his laboratory has focused particularly on the role of non-plaque MS parenchyma in the pathogenesis of the disease.
How did you become interested in MS research? What inspires you to continue advancing research in this field?
When I was practicing neurology, I was impressed by the degree of impairment that MS could inflict. At that time there was little or no treatment, even for relapses. I felt the best way to help these people affected by MS was to understand the disease mechanisms so that this knowledge will be eventually translated into effective treatment. I am convinced that studying diseased human tissue will significantly contribute to understanding of what is causing MS.
What do you enjoy most about doing research and what are some of the challenges you face?
The most enjoyable thing is the discovery of new knowledge and the realization that each new fact we uncover brings us one step closer to a cure. A major challenge is the fact that there are very few biobanks for human tissue for research in MS.
Describe the importance and level of collaboration in your research?
Collaboration is very important in my research. I collaborate with clinicians, physicists, diagnostic radiologists, neuroimmunologists and basic scientists in order to understand and interpret the changes we find in MS tissue.
How important is the support from the MS Society in enabling you to conduct research?
It is exceeding important. The MS Society is the major supporter of my research, not only at present but throughout my research career.