Multiple Sclerosis Society of Canada

Research We Fund

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Impact of IL-27 on MS pathobiology

Summary: IL-27 is a molecule that can diminish the severity of multiple sclerosis (MS) in a mouse model of the disease. Whether IL-27 is beneficial in individuals with MS is unresolved. The research team will: Compare the impact of IL-27 on immune cells from people with MS compared to those from healthy... Read the full article

Immigration and the risk of multiple sclerosis

Summary: Canada is known to have one of the highest multiple sclerosis (MS) rates in the world and while the risk of developing MS is lower in immigrants, it is still higher than in their native countries. It remains unknown why the Canadian environment may pose higher risk to develop MS. The research... Read the full article

It’s a fungal world: the mycobiome in pediatric MS

Co-Principal Investigators: Dr. Gary Van Domelaar, Dr. Charles Bernstein, Dr. Morag Graham Summary: The gut microbiome is home to trillions of microorganisms including bacteria, fungi, parasites, and viruses. The primary focus for researchers when studying the gut microbiome in multiple sclerosis (MS)... Read the full article

Progressive degeneration from onset in pediatric multiple sclerosis: Evaluation of clinical and health-related quality of life, early loss of brain integrity and accelerated immunological senescence

Investigators: Dr. Brenda Banwell , Children’s Hospital of Philadelphia Dr. Ruth Ann Marrie , Health Science Centre Winnipeg Dr. Amit Bar-Or , McGill University Dr. Douglas Arnold , McGill University Dr. Ann Yeh , Hospital for Sick Children Project Summary: Most people think of multiple sclerosis (MS)... Read the full article

Sex and Central Nervous System Autoimmunity

Affiliation: Toronto General Research Institute  Summary: One of the top risk factors for multiple sclerosis (MS) development is being female. Women outnumber men with this disease by 3-fold, and the reason is still unknown. There is a need to better understand the fundamental biological differences... Read the full article

The Role of EBV, B cells and NKT cells in MS

Summary: Epstein-Barr Virus (EBV) is the most common cause of infectious mononucleosis, an illness highly prevalent among adolescents. Adolescents and young adults with clinically diagnosed infectious mononucleosis have a high risk of developing multiple sclerosis (MS). The factors linking mononucleosis... Read the full article

Impact of IL-27 on MS pathobiology

Summary: IL-27 is a molecule that can diminish the severity of multiple sclerosis (MS) in a mouse model of the disease. Whether IL-27 is beneficial in individuals with MS is unresolved. The research team will: Compare the impact of IL-27 on immune cells from people with MS compared to those from healthy... Read the full article

The Role of Antibody-Secreting Cells in MS/EAE

Summary: B cells have a dual role in multiple sclerosis (MS). A subset of B cells slow the disease course in MS while another subset have detrimental effects on MS. The gut microbiome is the richest source of B cells. The role of a subset of B cells, called plasma cells, found in the gut microbiome... Read the full article

Improving cognition in people with Progressive Multiple Sclerosis: A Multi-Arm, Randomized, Blinded, Sham-Controlled Trial of Cognitive Rehabilitation and Aerobic Exercise

Project Summary: Cognition is considered an “invisible” symptom that can affect up to 70% of people with progressive MS and has been identified as an area of prime concern by people with MS given the harmful effects on employment, relationships and activities of daily living. There is an essential need... Read the full article

Web-based physiotherapy in moderate to severe MS

Project Description: Persons with MS may find it challenging to participate in regular physical activity or exercise, which is activity done to improve health and/or fitness. This is due to a number of reasons: exercise programs tailored to individuals with significant mobility impairments may be difficult... Read the full article

MRI of Deep Grey Matter in multiple sclerosis

Summary: Magnetic Resonance Imaging (MRI) is heavily used in multiple sclerosis (MS). It is highly effective for diagnosis of the disease. MRI is far less effective at tracking the disease progression and its response to therapy, largely due to reliance on only lesion measures. Other quantitative measures... Read the full article

Cancer in Multiple Sclerosis: Diagnosis and Outcomes

Summary: People with MS often have co-existing health conditions such as cancer. Cancer is the most common cause of death in people with MS after MS itself. Cancers of the breast, colon and rectum are among the most common cancers that affect Canadians, however we do not know very much about how often... Read the full article

Predicting Disease Deterioration in Multiple Sclerosis

Background: A current limitation in multiple sclerosis (MS) care is the ability to accurately predict whether a person’s MS will worsen and when, since the disease trajectory differs for each individual with MS. Being able to better predict a person’s disease trajectory can influence the healthcare... Read the full article

Sex Chromosomes Dictate T Cell (Th17) Pathogenicity

Background: A person’s sex is an important, yet complex factor in the development and progression of multiple sclerosis (MS). Current evidence indicates that women are three times more likely to develop MS than men, while men with MS progress more rapidly. While sex clearly impacts MS incidence and... Read the full article

Subclinical Atherosclerosis in Multiple Sclerosis

Background: Atherosclerosis is condition in which the arteries are narrowed due to a build-up of plaque. The plaque is made up of fat, cholesterol, clotting material from the blood and other factors. Atherosclerosis can occur silently without any clinical symptoms, this is called subclinical atherosclerosis... Read the full article

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