Multiple Sclerosis Society of Canada

Research in Alberta & the Northwest Territories

Researchers

Project Title
Researcher
Research Area
Affiliation
Funding Term
Funding
Examining sex differences in neuropathic pain behaviours in the EAE model Dr. Bradley Kerr Symptom Management and Quality of Life University of Alberta 2017-2020 $343 494
Elucidating the role and regulation of astrocytes in multiple sclerosis Dr. Shalina Ousman Mechanisms of Disease - Nerve Damage & Triggers of MS University of Calgary 2017-2020 $314 776.62
Inflammasome activation in the central nervous system: determinants and outcomes in progressive MS Dr. Christopher Power Mechanisms of Disease - Nerve Damage & Triggers of MS University of Alberta 2018-2021 $311 328
Expansion of antigen-specific regulatory networks for the treatment of CNS autoimmunity Dr. Pere Santamaria Therapy and Clinical Tool Development University of Calgary 2016-2019 $342 300
MRI of Deep Grey Matter in Multiple Sclerosis Dr. Alan Wilman Therapy and Clinical Tool Development University of Alberta 2017-2020 $280 500
Targeting novel functions of cysteine cathepsins to limit neuroinflammation Dr. Robin Yates Mechanisms of Disease - Trigger University of Calgary 2016-2019 $346 506
Elevated axonal and myelin injury with aging: Mechanisms, prevention and prospective therapeutics for progressive multiple sclerosis Dr. Wee Yong Mechanisms of Disease - Mechanisms of Progression University of Calgary 2018-2021 $420 140
Mechanisms and parameters of exercise-induced remyelination in mice Dr. Wee Yong Mechanisms of Disease - Repair University of Calgary 2016-2019 $412 636
Assessing remyelination in the presence of myelin debris using MRI Dr. Yunyan Zhang Therapy and Clinical Tool Development University of Calgary 2016-2019 $289 954

Trainees

Project Title
Trainee
Affiliation
Award
Research Area
Project Description


A novel mechanism of autoinflammatory induction by cysteine protease Cathepsin Z in multiple sclerosis Corey Arnold University of Calgary Postdoctoral Fellowship Mechanisms of Disease - Nerve Damage & Triggers of MS In multiple sclerosis, certain cells no longer pass a "safety inspection" by the immune system, and so the body begins to attack itself. The project focuses on how cells conduct this inspection, and reasons why it may go wrong.
Pilot Trial of Domperidone for Remyelination in Multiple Sclerosis Wei-Qiao Liu University of Calgary Studentship PhD MD Therapy and clinical tool development: domperidone for repair; advanced MRI to measure repair A major unmet need in the management of MS is improving the healing and repair of damage caused by relapses. The project is a clinical trial studying if domperidone (a safe oral drug) can improve repair in people with relapsing MS.
Aging exaggerates lesion size and axonal injury following demyelination: mechanisms and neuroprotection Nathan Michaels University of Calgary Studentship PhD Mechanisms of Disease - Progression Age is a critical risk factor for progressive Multiple Sclerosis (MS). The project investigates the underlying biology of age and lesion formation in the brain and spinal cord to better understand the mechanisms of progressive MS.
Development and characterization of animal models to study MS-related trigeminal neuralgia Kevin Thorburn University of Alberta Studentship PhD Mechanisms of Disease - Nerve Damage & Triggers of MS The primary goal of the project is to understand how the loss of myelin, and subsequent nerve damage, causes facial pain in MS. To study this, facial sensitivity in mice that have a disease very similar to MS is examined
Examining sex differences in central nervous system plasticity and pain in a mouse model of Multiple Sclerosis Ana Catuneanu University of Alberta Studentship Msc Cause and Risk Factors The goal of the research is to better understand how nerve cells in the pain processing areas of the spinal cord change during chronic pain development in an animal model of multiple sclerosis and how these changes differ between males and females.
miRNA in EAE-related pain: a new perspective on post-transcriptional regulation Timothy Friedman University of Alberta Studentship Msc Mechanisms of Disease - Repair Pain in MS is a major symptom for up to half of all MS patients. The project investigates how the expression of genes are controlled by small molecules called ‘microRNA’ and if a change in this control could result in the pain seen MS.
Innate Immune Responses in Oligodendrocytes and Therapeutic Strategies. Leina Saito University of Alberta Studentship Msc Mechanisms of Disease - Repair The project involves studying oligodendrocytes, which are brain cells that makes myelin, a protective factor for nerve fibres that is damaged in MS. The goal is to identify if oligodendrocytes are able to generate an immune response that may contribute to MS development.