Multiple Sclerosis Society of Canada

Research in Québec

Researchers

Project Title
Researcher
Research Area
Affiliation
Funding Term
Funding
Impact of IL-27 on MS pathobiology Dr. Nathalie Arbour Mechanisms of Disease - Repair Centre de Recherche du Centre Hospitalier de l’Université de Montréal 2017-2020 $383 138.25
Effects of FES cycling combining leg and trunk muscle stimulations in persons with multiple sclerosis: a pilot study Dr. Andreanne Blanchette Therapy and Clinical Tool Development Université Laval 2018-2021 $42 217
Immune cell influences on neuronal viability and repair Dr. Alyson Fournier Mechanisms of Disease - Mechanisms of Progression Montreal Neurological Institute 2016-2019 $370 512.06
Identifying New Molecular Mechanisms that Promote Myelin Maintenance and Remyelination Dr. Timothy Kennedy Mechanisms of Disease - Repair McGill University 2017-2020 $360 300
Molecular mechanisms underlying T cell/oligodendrocyte interactions as target for neuroprotective strategies in MS Dr. Catherine Larochelle Mechanisms of Disease - Repair Université de Montréal 2018-2021 $367 000
Targeting DICAM, a novel mediator of neuroinflammation, to treat MS Dr. Alexandre Prat Mechanisms of Disease - Nerve Damage & Triggers of MS Centre de Recherche du Centre Hospitalier de l’Université de Montréal 2018-2021 $360 000
Investigating a novel inhibitory signaling mechanism that represses T cell-driven CNS autoimmunity Dr. Manu Rangachari Mechanisms of Disease - Repair Université Laval 2017-2020 $299 259
Bacillus Calmette-Guerin (BCG) vaccination and multiple sclerosis: a population-based study in Quebec Dr. Marie-Claude Rousseau Cause and Risk Factors Institut national de la recherche scientifique (INRS) 2015-2019 $290 234
A Randomized, Controlled, Clinical Trial of Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea-Hypopnea in Multiple Sclerosis Dr. Daria Trojan Symptom Management and Quality of Life McGill University 2012-2019 $284 712.15
Role of neutrophils as antigen-presenting cells in autoimmune demyelination Dr. Luc Vallières Mechanisms of Disease - Mechanisms of Progression Laval university 2016-2019 $424 452

Trainees

Project Title
Trainee
Affiliation
Award
Research Area
Project Description


The therapeutic potential of the Th2 cytokine interleukin-13 in multiple sclerosis Chloé Hoornaert Centre de Recherche du Centre Hospitalier de l’Université de Montréal Postdoctoral Fellowship Mechanisms of Disease - Repair Having formerly established that the anti-inflammatory factor interleukin-13 is neuroprotective in a mouse model of MS (and other models of neuroinflammation), the goal of the project is to investigate if this factor also holds therapeutic promise in human MS.
Immune cells influence on neurodegeneration and neuroprotection through neuronal microRNAs regulation in the optic nerve Barbara Morquette Montreal Neurological Institute, McGill University Postdoctoral Fellowship Mechanisms of Disease - Nerve Damage & Triggers of MS The deterioration of nerve fibers is a major component of MS. The study will examine how immune cells trigger nerve damage and the associated underlying molecular mechanisms. This project will shed light on important therapeutic targets for MS patients.
The effect of the TH17-associated cytokine IL26 on CNS barriers integrity: Implications for MS Evelyn Peelen Centre de Recherche du CHUM Postdocotoral Fellowship Mechanisms of Disease - Repair A protein, called IL26, is shown to fortify the barrier between blood and brain to prevent harmful immune cells from entering. Although this suggests a beneficial role in MS, the project will further investigate the effect of IL26 on the defense system.
MCAM+ Cells Contribute to the Development of MS and Predict its Progression Marc Charabati Centre de Recherche du CHUM Studentship PhD Mechanisms of Disease - Nerve Damage & Triggers of MS In MS, harmful immune cells infiltrate the brain and spinal cord using specific cell surface molecules. The project aims at exploring the contribution of MCAM, a molecule present on the cell surface of blood vessels, to the development of MS.
Impact of IL-27 on T cells from Multiple Sclerosis patients Marie-Laure Clénet Centre de Recherche du CHUM Studentship PhD Mechanisms of Disease - Repair This study focuses on a molecule, called interleukin-27 (IL-27), whcih can diminish the severity of a mouse disease mimicking MS. However, the impact of IL-27 in people living with MS is still unknown.
NLRX1 acts as an endogenous inhibitor of multiple sclerosis Marjan Gharagozloo Université de Sherbrooke Studentship PhD Mechanisms of Disease - Progression The goal of the research is to investigate how molecules known as NOD-like receptors (NLRs) suppress initiation and progression of MS.
The role of integrin alpha8 in multiple sclerosis Elizabeth Gowing Centre de Recherche du CHUM Studentship PhD Mechanisms of Disease - Nerve Damage & Triggers of MS A group of proteins mediate the migration of inflammatory immune cells across the blood-brain barrier in MS. The study is identifying a new protein involved in this process, that if blocked therapeutically, has the potential to prevent MS disease activity.
Role of CD8+ T cells in progressive EAE. Prenitha Mercy Ignatius Arokia Doss Université Laval Studentship PhD Mechanisms of Disease - Progression Progressive multiple sclerosis (MS) is a phase of MS in which there is neurological deficit without recovery and immune cells play an important role in it. This project is generating a mouse model that can recapitulate progressive-MS seen in humans.
Elucidating Cortical Lesion Evolution in Multiple Sclerosis Josefina Maranzano McGill University Studentship PhD Mechanisms of Disease - Progression This project will identify and characterize the evolution of MS lesions that affect the a brain region using two different MRI scanners: one less powerful and available in clinical practice, the other, more powerful, only available for researchers.
The role of NKG2D in multiple sclerosis. Ana Carmena Moratalla Centre de Recherche du CHUM Studentship PhD Mechanisms of Disease - Nerve Damage & Triggers of MS Several studies showed that the immune system contributes to the development of multiple sclerosis (MS). This study investigates NKG2D, a molecule present on immune cells that may be involved in the damage of nerve cells in the brain of MS patients.
Investigating a Novel Mechanism that Promotes Myelin Maintenance Diane Nakamura McGill University Studentship PhD Mechanisms of Disease - Repair Mitochondria are an essential component of the cell responsible for energy and myelin production. The project aims to determine how energy production by mitochondria is regulated in the myelin-producing cells of the central nervous system.
Aging and Cognition in Multiple Sclerosis : The Role of Cognitive Reserve Alexandra Tremblay Université du Québec à Montréal Studentship PhD Symptom Management and Quality of Life As cognitive impairment is common in multiple sclerosis and the patients’ longevity is increasing, this study investigates cognitive aging in MS to better understand the symptomatology and to identify factors thay may promote successful aging.
Identify the contribution of netrin-1 and netrin receptors to remyelination following experimentally induced demyelination Samuel Clemot-DuPont McGill University Studentship Msc Mechanisms of Disease - Repair Myelin is the protective insulating substance of nerve fibers. Using a model of demyelination, loss of myelin following injury, the project aim to examine the contribution of proteins important for myelin maintenance, to myelin stability and repair.
Metabolic Control of Human Macrophage-Mediated Myelin Phagocytosis: Implications for MS Yun Hsuan (Elena) Lin Montreal Neurological Institute, McGill University Studentship Msc Mechanisms of Disease - Repair The project examines immune cells termed ‘macrophages’ responsible for cleaning toxic cellular debris built up in the brains of MS patients. The study focuses on understanding how the internal processes of these cells drive their beneficial function in disease.
Roles of miRNAs in neuron degeneration and repair Yang Zhang Montreal Neurological Institute, McGill University Studentship Msc Mechanisms of Disease - Nerve Damage & Triggers of MS The work aims to better understand the damage that brain cells undergo when they are faced with inflammatory challenges. Specifically, the project is looking at the changes that occur within brain cells and what interventions may prevent further damage from occuring.