Research We Fund

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A Randomized, Controlled, Clinical Trial of Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea-Hypopnea in Multiple Sclerosis

Summary: Poor sleep is a problem for many people with multiple sclerosis (MS) and is related to fatigue. Whether treatment of sleep disorders can markedly improve fatigue and other symptoms in some MS patients needs to be tested in a study. The research team is: Conducting a randomized, controlled, Read the full article

Understanding Multiple Sclerosis Cortical Pathology From a Neuroanatomical Perspective: Laminar Quantitative MRI Analysis of Cortical Neuroinflammation

Summary: MS is often characterized by the damage (or lesions) in the brain and spinal cord. One type of MS lesion particularly widespread is called a "sub-pial" cortical lesion. It lies along the surface of the brain. This research team is developing improved methods to detect "sub-pial" lesions using... Read the full article

Targeting Programs of Gene Expression to Enhance Neuroprotection

Background: Many of the current treatments for multiple sclerosis (MS) modulate the immune system and are generally ineffective at treating progressive forms of the disease. Nerve cell degeneration and death in the brain and spinal cord underlie progressive forms of the disease and disability in MS, Read the full article

AI & MS Discovery Grant: Artificial Intelligence Support for Treatment Decisions in the MS Clinic

Summary: Developing a clinical decision support tool for use by clinicians and people living with MS to make better, more personalized decisions on an individuals’ treatment plan Utilizes artificial intelligence and large-clinical trial datasets, including MRI images and clinical data, from over 10,000... Read the full article

Understanding the Role of Ependymal Cells in Multiple Sclerosis

Summary: Ependymal cells are important cells that line the fluid-filled spaces in the brain and regulate what flows in and out of the brain tissue. In MS, these cells may not be functioning well or are completely lost. As part of this research, Dr. Stratton and team will investigate how ependymal cells... Read the full article

Progressive degeneration from onset in pediatric multiple sclerosis: Evaluation of clinical and health-related quality of life, early loss of brain integrity and accelerated immunological senescence

Investigators: Dr. Brenda Banwell , Children’s Hospital of Philadelphia Dr. Ruth Ann Marrie , Health Science Centre Winnipeg Dr. Amit Bar-Or , McGill University Dr. Douglas Arnold , McGill University Dr. Ann Yeh , Hospital for Sick Children Project Summary: Most people think of multiple sclerosis (MS)... Read the full article