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Summary: VGF is a molecule that is induced during exercise and is shown to increase myelination. VGF also promotes the maturation of myelin-producing cells called oligodendrocytes. VGF interacts with macrophages/microglia- immune cells that can be both detrimental and beneficial in multiple sclerosis... Read the full article
Summary: Oligodendrocytes are myelin producing cells of the brain and spinal cord. Oligodendrocytes undergo morphological changes prior to producing myelin for nerve fibers. The factors regulating the steps involved in these morphological changes are unknown. The research team will: Modulate specific... Read the full article
Background: Multiple Sclerosis (MS) is a disease in which the insulation around the nerve fibres, known as myelin, becomes damaged by the immune system. This damage can result in loss of muscle control and partial paralysis. Oligodendrocytes are a specialized cell type that produce myelin sheaths around... Read the full article
Project Summary: The unique properties of stem cells make them promising candidates for treatments that can slow MS disease activity and repair tissue damage in the central nervous system. Mesenchymal stem cells (MSCs) are adult stem cells that can give rise to specific tissues and have demonstrated... Read the full article
