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Background: Many of the current treatments for multiple sclerosis (MS) modulate the immune system and are generally ineffective at treating progressive forms of the disease. Nerve cell degeneration and death in the brain and spinal cord underlie progressive forms of the disease and disability in MS, Read the full article
Summary: The onset of MS prior to age 18, during pivotal periods of cognitive maturation and development, has a profound impact on the child and their family. A fundamental unmet need is to understand the impact of pediatric-onset MS (POMS) and the recently identified myelin oligodendrocyte glycoprotein... Read the full article
Summary: Co-existing health conditions that can affect thinking and memory, such as high blood pressure or mood problems, are common in individuals with multiple sclerosis (MS). It is unknown whether common co-existing conditions including depression, anxiety, diabetes and high blood pressure increase... Read the full article
Summary: Canada is known to have one of the highest multiple sclerosis (MS) rates in the world and while the risk of developing MS is lower in immigrants, it is still higher than in their native countries. It remains unknown why the Canadian environment may pose higher risk to develop MS. The research... Read the full article
Summary: Mental illness during the peripartum period (during pregnancy and after delivery) poses serious health risks to parents and their children. Multiple sclerosis (MS) is associated with an increased incidence and prevalence of depression, anxiety disorders and bipolar disorder; yet little is known... Read the full article
Summary: One of the unmet needs is a better understanding of, and treatment options for, progression in MS. While current therapies in MS aim to slow the progression of the disease, there are no treatment options that successfully alter the trajectory of progression. A key to altering progression in... Read the full article
Summary: People with MS often have co-existing health conditions such as cancer. Cancer is the most common cause of death in people with MS after MS itself. Cancers of the breast, colon and rectum are among the most common cancers that affect Canadians, however we do not know very much about how often... Read the full article
