Multiple Sclerosis Society of Canada

Research We Fund

Filter Current filters include: Understand and Halt Disease Progression

Sex and Central Nervous System Autoimmunity

Affiliation: Toronto General Research Institute  Summary: One of the top risk factors for multiple sclerosis (MS) development is being female. Women outnumber men with this disease by 3-fold, and the reason is still unknown. There is a need to better understand the fundamental biological differences... Read the full article

Impact of IL-27 on MS pathobiology

Summary: IL-27 is a molecule that can diminish the severity of multiple sclerosis (MS) in a mouse model of the disease. Whether IL-27 is beneficial in individuals with MS is unresolved. The research team will: Compare the impact of IL-27 on immune cells from people with MS compared to those from healthy... Read the full article

The Role of Antibody-Secreting Cells in MS/EAE

Summary: B cells have a dual role in multiple sclerosis (MS). A subset of B cells slow the disease course in MS while another subset have detrimental effects on MS. The gut microbiome is the richest source of B cells. The role of a subset of B cells, called plasma cells, found in the gut microbiome... Read the full article

Predicting Disease Deterioration in Multiple Sclerosis

Background: A current limitation in multiple sclerosis (MS) care is the ability to accurately predict whether a person’s MS will worsen and when, since the disease trajectory differs for each individual with MS. Being able to better predict a person’s disease trajectory can influence the healthcare... Read the full article

Sex Chromosomes Dictate T Cell (Th17) Pathogenicity

Background: A person’s sex is an important, yet complex factor in the development and progression of multiple sclerosis (MS). Current evidence indicates that women are three times more likely to develop MS than men, while men with MS progress more rapidly. While sex clearly impacts MS incidence and... Read the full article

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