Multiple Sclerosis Society of Canada

Research We Fund

Filter Current filters include: Understand and Halt Disease Progression

Sex and Central Nervous System Autoimmunity

Affiliation: Toronto General Research Institute  Summary: One of the top risk factors for multiple sclerosis (MS) development is being female. Women outnumber men with this disease by 3-fold, and the reason is still unknown. There is a need to better understand the fundamental biological differences... Read the full article

Impact of IL-27 on MS pathobiology

Summary: IL-27 is a molecule that can diminish the severity of multiple sclerosis (MS) in a mouse model of the disease. Whether IL-27 is beneficial in individuals with MS is unresolved. The research team will: Compare the impact of IL-27 on immune cells from people with MS compared to those from healthy... Read the full article

The Role of Antibody-Secreting Cells in MS/EAE

Summary: B cells have a dual role in multiple sclerosis (MS). A subset of B cells slow the disease course in MS while another subset have detrimental effects on MS. The gut microbiome is the richest source of B cells. The role of a subset of B cells, called plasma cells, found in the gut microbiome... Read the full article

Predicting Disease Deterioration in Multiple Sclerosis

Background: A current limitation in multiple sclerosis (MS) care is the ability to accurately predict whether a person’s MS will worsen and when, since the disease trajectory differs for each individual with MS. Being able to better predict a person’s disease trajectory can influence the healthcare... Read the full article

Sex Chromosomes Dictate T Cell (Th17) Pathogenicity

Background: A person’s sex is an important, yet complex factor in the development and progression of multiple sclerosis (MS). Current evidence indicates that 75% of people in Canada living with MS are women - women are three times more likely to develop MS than men, while men with MS progress more rapidly... Read the full article

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