Multiple Sclerosis Society of Canada

Research We Fund

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The Role of EBV, B cells and NKT cells in MS

Summary: Epstein-Barr Virus (EBV) is the most common cause of infectious mononucleosis, an illness highly prevalent among adolescents. Adolescents and young adults with clinically diagnosed infectious mononucleosis have a high risk of developing multiple sclerosis (MS). The factors linking mononucleosis... Read the full article

Immigration and the risk of multiple sclerosis

Summary: Canada is known to have one of the highest multiple sclerosis (MS) rates in the world and while the risk of developing MS is lower in immigrants, it is still higher than in their native countries. It remains unknown why the Canadian environment may pose higher risk to develop MS. The research... Read the full article

Impact of IL-27 on MS pathobiology

Summary: IL-27 is a molecule that can diminish the severity of multiple sclerosis (MS) in a mouse model of the disease. Whether IL-27 is beneficial in individuals with MS is unresolved. The research team will: Compare the impact of IL-27 on immune cells from people with MS compared to those from healthy... Read the full article

Progressive degeneration from onset in pediatric multiple sclerosis: Evaluation of clinical and health-related quality of life, early loss of brain integrity and accelerated immunological senescence

Investigators: Dr. Brenda Banwell , Children’s Hospital of Philadelphia Dr. Ruth Ann Marrie , Health Science Centre Winnipeg Dr. Amit Bar-Or , McGill University Dr. Douglas Arnold , McGill University Dr. Ann Yeh , Hospital for Sick Children Project Summary: Most people think of multiple sclerosis (MS)... Read the full article

The Role of Antibody-Secreting Cells in MS/EAE

Summary: B cells have a dual role in multiple sclerosis (MS). A subset of B cells slow the disease course in MS while another subset have detrimental effects on MS. The gut microbiome is the richest source of B cells. The role of a subset of B cells, called plasma cells, found in the gut microbiome... Read the full article

It’s a fungal world: the mycobiome in pediatric MS

Co-Principal Investigators: Dr. Gary Van Domelaar, Dr. Charles Bernstein, Dr. Morag Graham Summary: The gut microbiome is home to trillions of microorganisms including bacteria, fungi, parasites, and viruses. The primary focus for researchers when studying the gut microbiome in multiple sclerosis (MS)... Read the full article

Sex and Central Nervous System Autoimmunity

Affiliation: Toronto General Research Institute  Summary: One of the top risk factors for multiple sclerosis (MS) development is being female. Women outnumber men with this disease by 3-fold, and the reason is still unknown. There is a need to better understand the fundamental biological differences... Read the full article

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