Research We Fund

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Hierarchy of Inhibitors in the Lesion Microenvironment for Remyelination: Combining a Novel CNS-Targeting Therapeutic with Exercise to Promote Repair

Summary: MS results from abnormal activity of the immune system whereby the body’s own immune cells target and damage myelin (the outer protective coating of nerve fibers) and myelin-producing cells called oligodendrocytes located in the central nervous system. Regeneration of oligodendrocytes and subsequent... Read the full article

Elevated axonal and myelin injury with aging: Mechanisms, prevention and prospective therapeutics for progressive multiple sclerosis

Summary: Age is a key factor associated with progression from relapsing to progressive forms of multiple sclerosis (MS). Destructive oxygen radicals are activated in MS and may play a role in age-dependent injury. How they are activated and cause injury is unknown. The research team will: Examine aging-enhanced... Read the full article

Mechanisms and parameters of exercise-induced remyelination in mice

Summary: Over the past few decades, research has uncovered considerable benefits associated with physical activity, particularly with improving symptoms of multiple sclerosis (MS). Whether physical activity after mice are experimentally induced with an MS-like condition would enhance repair processes... Read the full article